مقایسه پاسخ بافتی اطراف سه نوع نخ بخیه سیلک غیرقابل جذب چند رشته ای: یک مطالعه حیوانی

Introduction: The tissue reaction to stitch strings used in the intraoral surgery that can aggravate inflammation is an important issue. This study aimed to compare the tissue reaction formed around three types of stitches, including Demesilk (Demetech corporation,USA) that is not produced inside the country, Pedsilk and Suture, which all are natural nonabsorbable, on rats. Methods: In this experimental study, 12 male rats with an approximate weight of 250 g were selected and divided into two equal groups. After anesthesia, the back hair of the animals was shaved and all three types of stitch strings were used differently in each sample. The first type of stitch was Pedsilk, the second type Suture, and the third one was Demesilk. In certain days (the second and seventh days), one group of the rats were sacrificed with a certain amount of fatal ketamine and all three types of stitch strings were removed separately and transmitted to laboratory and compared regarding inflammation, granulation and fibrosis formation. The data were analyzed using the Friedman and Wilcoxon tests with the SPPS software. Results: Statistical assessment carried out in all three types showed a significant difference among the strings in most cases. The manner of Pedsilk and Demesilk with regard to inflammation was similar in which the possibility of inflammation increased as the time passed and this possibility decreased in the Suture. The manner of both Pedsilk and Demesilk regarding the granulation tissue was similar in which the possibility of the formation of the tissue did not have a remarkable decrease as the time passed. In Suture, this possibility decreased remarkably. The manner of all three strings, Suture, Pedsilk and Demesilk, increased significantly regarding fibrosis tissue formation as the time passed (P < 0.05). After a while, the possibility of Rey epithelialization increased meaningfully in Suture and Demesilk, while it remained unchanged in Pedesilk. The string of Suture was distinguished as the best string in comparison with the two other types. Conclusion: The common use of stitch strings in intraoral surgeries and the fact that a stitch string is considered as an external body in a wound zone increases the risk of infection and inflammation in Demesilk and Pedsilk, but this possibility decreases in the Suture type. As a result, after the surgery, the use of the Suture in covering the surgery zone is supposed to be the most important factor in amending the tissue and the success of the surgery. &nbsp;